Oleolive Wins Pivotal Small Business Research award for Oleocanthal in Triple Negative Breast Cancer
Today, May 26th 2020, Oleolive, LLC, a preclinical stage life sciences company, received an official notice of award from the National Cancer Institute (NCI) and National Institutes of Health to...Read more
Oleolive awarded NIH funding to study oleocanthal and alzheimers
Oleolive is incredibly excited to announce our award by the NIH (National Institutes of Health) and NIA (National Institue on Aging) to further our efforts in studying oleocanthal for the...Read more
The olive-based oleocanthal as a dual HER2-MET inhibitor for the control of breast cancer recurrence
Authors: Abu Bakar Siddique, Hassan Ebrahim, Mohamed Mohyeldin, Seetharama D. Jois and Khalid A. El Sayed Abstract: Dysregulation of the receptor tyrosine kinases (RTKs) HER2 and c-Met correlate well with...Read more
Oleocanthal-rich extra-virgin olive oil enhances donepezil effect by reducing amyloid-β load and related toxicity in a mouse model of Alzheimer's disease.
Authors: Batarseh YS1, Kaddoumi A2. Abstract: Previous evidence suggested that extra-virgin olive oil (EVOO) is linked to attenuating amyloid-β (Aβ) pathology and improving cognitive function in Alzheimer's disease (AD) mouse models....Read more
OLIGEN approved by INCI as first Trade Name for Oleocanthal
As part of Oleolive’s intellectual property strategy, the name OLIGEN was trademarked as the company’s brand of oleocanthal. Subsequently, upon claiming the OLIGEN trade name, the company applied with the...Read more
Oleocanthal enhances amyloid-β clearance from the brains of TgSwDI mice and in vitro across a human blood-brain barrier model.
Authors: Qosa H1, Batarseh YS1, Mohyeldin MM1, El Sayed KA1, Keller JN2, Kaddoumi A1. Abstract: Numerous clinical and preclinical studies have suggested several health promoting effects for the dietary consumption of extra-virgin olive oil (EVOO) that...Read more
The oleocanthal-based homovanillyl sinapate as a novel c-Met inhibitor.
Authors: Mohyeldin MM1, Akl MR1, Ebrahim HY1, Dragoi AM2, Dykes S2, Cardelli JA2, El Sayed KA1. Abstract: The hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (c-Met) signaling axis has gained considerable attention as an attractive molecular target for...Read more
Oleocanthal ameliorates amyloid-β oligomers' toxicity on astrocytes and neuronal cells: In vitro studies.
Authors: Batarseh YS1, Mohamed LA1, Al Rihani SB1, Mousa YM1, Siddique AB1, El Sayed KA1, Kaddoumi A2. Abstract: Extra-virgin olive oil (EVOO) has several health promoting effects. Evidence have shown that EVOO attenuates the pathology of amyloid-β...Read more